Tuesday, January 19, 2021
Many human viruses have cation-selective transmembrane ion channels that are important for the virus lifecycle and pathogenesis. Researchers at MIT’s Hong Lab have determined the structures of a SARS-CoV-2 viroporin, the envelope protein E, and the influenza viroporin, M2, using nuclear magnetic resonance spectroscopy. This molecular structural information sets the stage for developing antiviral drugs to inhibit these viroporins.
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